The interactive serious game Wind Tales is ready for the first clinical trial at the University Medical Center Utrecht. Tremendous progress has been made to achieve dynamic in-depth multi-level game content in which the player can feel at home in part of the Wind Tales’ world like the jungle, the underwater world or the desert, to be fully immersed in the game. Free game play is combined with the full set of breathing techniques and exercises, all adapted to the personal needs of the player and played with the Wind Tales unique breathing controlled game controller. Additional interactive gameplay has been developed to train a lung function test allowing therapy follow-up and remote monitoring.